Wednesday, 15 September 2021
Beşiktaş v B. Dortmund (Vodafone Park) at 19:45 Turkish Time
Tuesday, 28 September 2021
Ajax v Beşiktaş (Johan Cruyff Arena) at 19:45 Turkish Time
Tuesday, 19 October 2021
Beşiktaş v Sporting CP (Vodafone Park) at 19:45 Turkish Time
Wednesday, 3 November 2021
Sporting CP v Beşiktaş (Jose Alvalade) at 23:00 Turkish Time
Wednesday, 24 November 2021
Beşiktaş v Ajax (Vodafone Park) at 20:45 Turkish Time
Tuesday, 7 December 2021
B. Dortmund v Beşiktaş (Signal Iduna at 23:00 Turkish Time
