With only a goal separating them, the teams started extremely cautious at the back, but the home side Beşiktaş managed to go ahead after 27 minutes through Anderson Talisca. The French visitors recovered quickly and responded with a 34th-minute flick from Alexandre Lacazatte, who made sure that the first half ended one-all.
Needing a goal to stay alive, the Black Eagles opened the second-half with attacks from both flanks and regained the lead on 58 minutes, thanks to Anderson Talisca’s powerful header. The two sides tried hard to change the outcome in the remaining minutes, but with the aggregate scores level, the game went into the extra time. There were no goals in the additional 30 minutes, so the match moved on to the penalty-kicks. Lyon won the shoot-out 7-6 and progressed to the Europa League Semi-Finals.