Beşiktaş started the brighter and saw their red-hot striker Vincent Aboubakar give them a 1-0 lead just after 10 minutes, with a close-range header off Talisca’s well-timed cross. Twelve minutes later, Ryan Babel unleashed a bullet from inside the box to make it 2-0 for the home side. However,Tarik Elyounoussi volleyed home for the visitors to reduce the deficit to one at the 31st-minute mark, bringing the Olympiacos back into game. Then Aboubakar left Beşiktaş a man short with an unnecessary red card heading to the break.
The shorthanded but determined Eagles tightened up on defence before finding two more goals through Ryan Babel and Cenk Tosun to win the second leg 4-1 and advance to the Europa League quarter-finals.